spiralngphoenix (![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png)
spiralngphoenix) wrote2010-08-05 12:31 am
spiralngphoenix) wrote2010-08-05 12:31 am
Entry tags:
(no subject)
Ooh look! Even more reasons to avoid high fructose corn syrup like the Plague...
Cancer cells found to thrive on fructose.
The Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth
Abstract
Carbohydrate metabolism via glycolysis and the tricarboxylic acid cycle is pivotal for cancer growth, and increased refined carbohydrate consumption adversely affects cancer survival. Traditionally, glucose and fructose have been considered as interchangeable monosaccharide substrates that are similarly metabolized, and little attention has been given to sugars other than glucose. However, fructose intake has increased dramatically in recent decades and cellular uptake of glucose and fructose uses distinct transporters. Here, we report that fructose provides an alternative substrate to induce pancreatic cancer cell proliferation. Importantly, fructose and glucose metabolism are quite different; in comparison with glucose, fructose induces thiamine-dependent transketolase flux and is preferentially metabolized via the nonoxidative pentose phosphate pathway to synthesize nucleic acids and increase uric acid production. These findings show that cancer cells can readily metabolize fructose to increase proliferation. They have major significance for cancer patients given dietary refined fructose consumption, and indicate that efforts to reduce refined fructose intake or inhibit fructose-mediated actions may disrupt cancer growth. Cancer Res; 70(15); 6368–76. ©2010 AACR. of the research paper published in the current (July) issue of Cancer Research Journal
Cancer cells found to thrive on fructose.
The Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth
Abstract
Carbohydrate metabolism via glycolysis and the tricarboxylic acid cycle is pivotal for cancer growth, and increased refined carbohydrate consumption adversely affects cancer survival. Traditionally, glucose and fructose have been considered as interchangeable monosaccharide substrates that are similarly metabolized, and little attention has been given to sugars other than glucose. However, fructose intake has increased dramatically in recent decades and cellular uptake of glucose and fructose uses distinct transporters. Here, we report that fructose provides an alternative substrate to induce pancreatic cancer cell proliferation. Importantly, fructose and glucose metabolism are quite different; in comparison with glucose, fructose induces thiamine-dependent transketolase flux and is preferentially metabolized via the nonoxidative pentose phosphate pathway to synthesize nucleic acids and increase uric acid production. These findings show that cancer cells can readily metabolize fructose to increase proliferation. They have major significance for cancer patients given dietary refined fructose consumption, and indicate that efforts to reduce refined fructose intake or inhibit fructose-mediated actions may disrupt cancer growth. Cancer Res; 70(15); 6368–76. ©2010 AACR. of the research paper published in the current (July) issue of Cancer Research Journal
no subject
Too much of anything is bad. I reference HFCS here mainly because a.) it's the most prevalent source of fructose in our diets, and b.) by it's very nature, it is a higher source of fructose that others, hence it's name. (I have a few other gripes about it, too, in that I hate eating food that has been genetically tampered with, and corn is one of the worst for that. Having it in my english muffins makes me cranky. ;) )
The state of science reporting also makes me cranky. I'm seeing if I can find the actual study and read it for myself, but figured it's also one of those things that it's potentially handy for people to at least look into.
no subject
The summary I got was basically, "We think it's neat how fructose and glucose are used differently by cancer cells. Isn't that cool?"
no subject
A little more than "Isn't that cool?". ;)